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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1982 1
1983 2
1985 4
1986 2
1987 1
1989 1
1990 1
1993 3
1994 4
1995 1
1996 1
1997 3
1998 1
1999 1
2000 1
2001 1
2002 1
2003 3
2004 5
2005 2
2006 3
2007 8
2008 3
2009 6
2010 5
2011 9
2012 8
2013 9
2014 16
2015 19
2016 11
2017 18
2018 14
2019 14
2020 16
2021 15
2022 12
2023 10
2024 3

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215 results

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Page 1
A novel antibiotic class targeting the lipopolysaccharide transporter.
Zampaloni C, Mattei P, Bleicher K, Winther L, Thäte C, Bucher C, Adam JM, Alanine A, Amrein KE, Baidin V, Bieniossek C, Bissantz C, Boess F, Cantrill C, Clairfeuille T, Dey F, Di Giorgio P, du Castel P, Dylus D, Dzygiel P, Felici A, García-Alcalde F, Haldimann A, Leipner M, Leyn S, Louvel S, Misson P, Osterman A, Pahil K, Rigo S, Schäublin A, Scharf S, Schmitz P, Stoll T, Trauner A, Zoffmann S, Kahne D, Young JAT, Lobritz MA, Bradley KA. Zampaloni C, et al. Nature. 2024 Jan;625(7995):566-571. doi: 10.1038/s41586-023-06873-0. Epub 2024 Jan 3. Nature. 2024. PMID: 38172634 Free PMC article.
A clinical candidate derived from the MCP class, zosurabalpin (RG6006), effectively treats highly drug-resistant contemporary isolates of CRAB both in vitro and in mouse models of infection, overcoming existing antibiotic resistance mechanisms. ...
A clinical candidate derived from the MCP class, zosurabalpin (RG6006), effectively treats highly drug-resistant contemporary isolates of CR …
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer.
Alam A, Levanduski E, Denz P, Villavicencio HS, Bhatta M, Alhorebi L, Zhang Y, Gomez EC, Morreale B, Senchanthisai S, Li J, Turowski SG, Sexton S, Sait SJ, Singh PK, Wang J, Maitra A, Kalinski P, DePinho RA, Wang H, Liao W, Abrams SI, Segal BH, Dey P. Alam A, et al. Cancer Cell. 2022 Feb 14;40(2):153-167.e11. doi: 10.1016/j.ccell.2022.01.003. Epub 2022 Feb 3. Cancer Cell. 2022. PMID: 35120601 Free PMC article.
Pesticides and cancer.
Dich J, Zahm SH, Hanberg A, Adami HO. Dich J, et al. Cancer Causes Control. 1997 May;8(3):420-43. doi: 10.1023/a:1018413522959. Cancer Causes Control. 1997. PMID: 9498903 Review.
Epidemiologic evidence on the relationship between chemical pesticides and cancer is reviewed. In animal studies, many pesticides are carcinogenic, (e.g., organochlorines, creosote, and sulfallate) while others (notably, the organochlorines DDT, chlordane, and lindane) are …
Epidemiologic evidence on the relationship between chemical pesticides and cancer is reviewed. In animal studies, many pesticides are …
Animal models of soft-tissue sarcoma.
Dodd RD, Mito JK, Kirsch DG. Dodd RD, et al. Dis Model Mech. 2010 Sep-Oct;3(9-10):557-66. doi: 10.1242/dmm.005223. Epub 2010 Aug 16. Dis Model Mech. 2010. PMID: 20713645 Free PMC article. Review.
Model organisms might provide traction to our understanding and treatment of the disease. Over the past 10 years, many successful animal models of STS have been developed, primarily genetically engineered mice and zebrafish. ...Recently, these model sy …
Model organisms might provide traction to our understanding and treatment of the disease. Over the past 10 years, many successful …
NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.
Olszewski RT, Janczura KJ, Bzdega T, Der EK, Venzor F, O'Rourke B, Hark TJ, Craddock KE, Balasubramanian S, Moussa C, Neale JH. Olszewski RT, et al. Neurochem Res. 2017 Sep;42(9):2646-2657. doi: 10.1007/s11064-017-2181-4. Epub 2017 Mar 11. Neurochem Res. 2017. PMID: 28285415 Free PMC article.
Inhibitors of GCPII increase extracellular NAAG levels and are efficacious in animal models of clinical disorders via NAAG activation of a group II metabotropic glutamate receptor. mGluR2 and mGluR3 knock-out (ko) mice were used to test the hypothesis that mGluR3 me …
Inhibitors of GCPII increase extracellular NAAG levels and are efficacious in animal models of clinical disorders via NAAG act …
Sodium thiosulfate ameliorates atopic dermatitis via inhibiting the activation of NLRP3 inflammasome.
Wang D, Liu Y, Zong X, Li X, Yang S, Zeng Y, Lu J. Wang D, et al. Biochem Biophys Res Commun. 2023 Sep 17;673:160-168. doi: 10.1016/j.bbrc.2023.06.072. Epub 2023 Jun 24. Biochem Biophys Res Commun. 2023. PMID: 37392479
Therefore, this study revealed that STS plays an important therapeutic role in AD, and the mechanism may be that STS inhibits the activation of NLRP3 inflammasome and the subsequent release of inflammatory cytokines. Thus, the role of STS in treating AD was c …
Therefore, this study revealed that STS plays an important therapeutic role in AD, and the mechanism may be that STS inhibits …
Inhibition of GSDMD-mediated pyroptosis triggered by Trichinella spiralis intervention contributes to the alleviation of DSS-induced ulcerative colitis in mice.
Ma ZR, Li ZL, Zhang N, Lu B, Li XW, Huang YH, Nouhoum D, Liu XS, Xiao KC, Cai LT, Xu SR, Yang XO, Huang SQ, Wu X. Ma ZR, et al. Parasit Vectors. 2023 Aug 14;16(1):280. doi: 10.1186/s13071-023-05857-3. Parasit Vectors. 2023. PMID: 37580819 Free PMC article.
BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is increasing worldwide. ...
BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is increasing worldw …
Safety and efficacy of tamoxifen in boys with Duchenne muscular dystrophy (TAMDMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Henzi BC, Schmidt S, Nagy S, Rubino-Nacht D, Schaedelin S, Putananickal N, Stimpson G; North Star Consortium; Amthor H, Childs AM, Deconinck N, de Groot I, Horrocks I, Houwen-van Opstal S, Laugel V, Lopez Lobato M, Madruga Garrido M, Nascimento Osorio A, Schara-Schmidt U, Spinty S, von Moers A, Lawrence F, Hafner P, Dorchies OM, Fischer D. Henzi BC, et al. Lancet Neurol. 2023 Oct;22(10):890-899. doi: 10.1016/S1474-4422(23)00285-5. Lancet Neurol. 2023. PMID: 37739572 Clinical Trial.
INTERPRETATION: Tamoxifen was safe and well tolerated, but no difference between groups was reported for the primary efficacy endpoint. Slower disease progression, defined by loss of motor function over time, was indicated in the tamoxifen group compared with the placebo g …
INTERPRETATION: Tamoxifen was safe and well tolerated, but no difference between groups was reported for the primary efficacy endpoint. Slow …
Wistar-Kyoto rats and chronically stressed Wistar rats present similar depression- and anxiety-like behaviors but different corticosterone and endocannabinoid system modulation.
Wang Z, van Bruggen R, Sandini T, Hagen EV, Li XM, Zhang Y. Wang Z, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20;127:110825. doi: 10.1016/j.pnpbp.2023.110825. Epub 2023 Jul 10. Prog Neuropsychopharmacol Biol Psychiatry. 2023. PMID: 37437836
In addition, the Luminex assay revealed that WKY rats showed a higher resilience on the HPA-axis modulation towards chronic SIS, distinguished by the hyperactivity of the HPA-axis modulation in WIS rats. Overall, the study revealed that the chronic SIS animal model (stress …
In addition, the Luminex assay revealed that WKY rats showed a higher resilience on the HPA-axis modulation towards chronic SIS, distinguish …
215 results